Name: Spicy Southern Cheesy Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Cuisine: Southern
Ingredients: 3–4 boneless, skinless chicken breasts (about 1.5 lbs); 8 oz spaghetti; 2 cups shredded sharp cheddar cheese; 1 cup fresh bell peppers, chopped; 1 can (10.5 oz) cream of chicken soup; 1 tsp paprika; ½ tsp cayenne pepper; 1 tsp garlic powder; ¼ cup green onions, sliced

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This Spicy Southern Cheesy Chicken Spaghetti Casserole is pure comfort in a baking dish. I love how the creamy texture, melty cheese, and bold spices come together with tender chicken and pasta to create a dish that’s rich, hearty, and incredibly satisfying. Whether I’m feeding a crowd or just craving something warm and filling, this recipe hits all the right notes.

Why You’ll Love This Recipe

I love this recipe because it’s easy, versatile, and packed with flavor. The combination of paprika and cayenne gives it just the right kick, while the cheddar cheese melts into every bite for that irresistible Southern-style creaminess. It’s perfect for meal prep, potlucks, or cozy dinners at home, and I can customize it with whatever I have on hand—extra veggies, more heat, or different cheeses.

Ingredients

(Here’s a tip: Check out the full list of ingredients and measurements in the recipe card below.)

3–4 boneless, skinless chicken breasts (about 1.5 lbs)
8 oz spaghetti
2 cups shredded sharp cheddar cheese
1 cup fresh bell peppers, chopped
1 can (10.5 oz) cream of chicken soup
1 tsp paprika
½ tsp cayenne pepper
1 tsp garlic powder
¼ cup green onions, sliced

Directions

I preheat the oven to 350°F (175°C) and grease a large casserole dish.
In a large pot, I cook the chicken over medium heat for 6–7 minutes per side until golden and fully cooked. I let it rest for a few minutes, then shred it into bite-sized pieces.
While the chicken cooks, I boil a pot of salted water and cook the spaghetti until al dente, about 8–10 minutes. I drain it and set it aside.
In a large mixing bowl, I combine the shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne pepper, garlic powder, and half the shredded cheddar cheese. I stir until everything is well mixed.
I pour the mixture into the prepared casserole dish and spread it evenly. Then I top it with the remaining cheddar cheese.
I bake it uncovered for 25–30 minutes, or until the top is bubbly and golden brown.
After baking, I let the casserole rest for 5 minutes, then sprinkle it with sliced green onions before serving.

Servings and timing

This recipe serves 8 people.

Prep time: 15 minutes
Cook time: 30 minutes
Total time: 45 minutes

Variations

Extra spicy: I add chopped jalapeños or a dash of hot sauce to amp up the heat.
Cheese swap: I mix in Monterey Jack or Pepper Jack for more creaminess and spice.
Veggie-loaded: I toss in sautéed mushrooms, spinach, or corn to stretch it further.
Creamy upgrade: I stir in a splash of milk or cream for a silkier sauce.
Rotisserie shortcut: I use shredded rotisserie chicken to save time.

Storage/Reheating

I store leftovers in an airtight container in the fridge for up to 3 days.
To reheat, I bake it covered at 350°F until warmed through or microwave individual portions for 1–2 minutes. I add a splash of water or broth if it seems dry.

FAQs

Can I make this ahead of time?

Yes! I assemble everything and refrigerate it unbaked for up to 24 hours. When ready to serve, I bake it as directed.

Can I freeze this casserole?

Absolutely. I freeze the assembled (but unbaked) casserole for up to 3 months. I thaw it in the fridge overnight and bake it as usual.

What can I use instead of cream of chicken soup?

I make a quick substitute using a roux (butter + flour) with chicken broth and a bit of milk. Or I use a homemade cream sauce with garlic, broth, and seasoning.

What type of spaghetti works best?

I use regular spaghetti, but whole grain or even gluten-free spaghetti works fine too—just don’t overcook it.

Is this dish kid-friendly?

Yes—though if I’m serving kids, I reduce the cayenne or omit it. I can always add heat later for my portion.

Conclusion

This Spicy Southern Cheesy Chicken Spaghetti Casserole is one of those dependable, feel-good meals that I keep coming back to. It’s cheesy, creamy, a little spicy, and totally satisfying. Whether I’m making it for a busy weeknight or sharing it at a potluck, this dish always delivers big Southern comfort with minimal effort.