This Chicken Alfredo Bake is my go-to when I want a rich, comforting dinner that satisfies everyone at the table. With tender chicken, perfectly cooked penne pasta, and a creamy homemade Alfredo sauce, it’s everything I love about a classic pasta dish—baked to golden, cheesy perfection. Topped with an Italian Five Cheese Blend, this bake turns any dinner into something special.

Why You’ll Love This Recipe

I love this recipe because it brings together simple ingredients in a way that feels indulgent and cozy. It’s great for meal prepping, feeding a crowd, or just treating my family to something hearty. The chicken is flavorful, the Alfredo sauce is creamy and smooth, and the baked cheese topping gives it that irresistible, bubbly finish.

Ingredients

(Here’s a tip: Check out the full list of ingredients and measurements in the recipe card below.)

12 oz penne pasta
3 boneless, skinless chicken breasts (marinated in Italian dressing, optional)
2 tablespoons olive oil
Salt and pepper, to taste
2 tablespoons butter
3 cloves garlic, minced
2 cups heavy cream
1 cup grated Parmesan cheese
1 teaspoon Italian seasoning
1 ½ cups shredded Italian Five Cheese Blend (for topping)
Fresh parsley (optional, for garnish)

Directions

I preheat the oven to 375°F and lightly grease a 9×13-inch baking dish.
I cook the penne pasta according to package directions until al dente, then drain and set aside.
While the pasta cooks, I season the chicken breasts with salt and pepper (or marinate them in Italian dressing for extra flavor).
In a skillet over medium heat, I heat olive oil and cook the chicken until golden and cooked through, about 5–7 minutes per side. I then let it rest for a few minutes before slicing it into bite-sized pieces.
In the same skillet, I melt butter and sauté the garlic for about 1 minute. Then I pour in the heavy cream and bring it to a gentle simmer.
I stir in the Parmesan cheese and Italian seasoning, letting the sauce cook for 3–5 minutes until slightly thickened.
I combine the cooked pasta, sliced chicken, and Alfredo sauce in a large bowl and mix everything well.
I transfer the mixture to the prepared baking dish and sprinkle the Italian Five Cheese Blend evenly over the top.
I bake for 20–25 minutes, or until the cheese is melted and bubbly. For a golden top, I broil it for the last 2–3 minutes.
I remove it from the oven and let it sit for a few minutes before garnishing with parsley and serving.

Servings and timing

This recipe makes 6 servings and takes about 45–50 minutes from start to finish, including prep, cooking, and baking time.

Variations

I sometimes add steamed broccoli or spinach for extra veggies.
For a smoky flavor, I substitute grilled or rotisserie chicken.
When I want a spicy twist, I add a pinch of red pepper flakes to the Alfredo sauce.
I’ve used fettuccine or rotini instead of penne—any sturdy pasta works well.
A sprinkle of breadcrumbs mixed with melted butter makes a great crunchy topping.

Storage/Reheating

Leftovers keep well in an airtight container in the fridge for up to 4 days. To reheat, I microwave individual portions or warm the whole dish in the oven at 350°F until heated through. I add a splash of cream or milk before reheating to keep the sauce creamy.

FAQs

Can I use jarred Alfredo sauce?

Yes, I’ve used jarred Alfredo in a pinch. I just doctor it up with garlic, seasoning, and a bit of extra Parmesan to boost the flavor.

Can I make this ahead of time?

Absolutely. I often assemble the dish ahead and refrigerate it until ready to bake. I just add 5–10 extra minutes to the baking time if it’s going in cold.

What cheese is in the Italian Five Cheese Blend?

It usually includes mozzarella, provolone, Parmesan, Romano, and Asiago. It melts beautifully and adds great flavor to the topping.

Can I freeze this dish?

Yes, I freeze it before baking. I wrap the dish tightly in foil and freeze for up to 2 months. When ready to bake, I thaw it overnight in the fridge and bake as directed.

What should I serve with Chicken Alfredo Bake?

I usually serve it with garlic bread and a fresh green salad. Roasted vegetables or steamed broccoli also make great sides.

Conclusion

Chicken Alfredo Bake is the kind of recipe I turn to when I want something warm, creamy, and guaranteed to make everyone at the table happy. It’s simple, hearty, and packed with flavor—perfect for a family dinner, potluck, or even just a cozy night in. Once it’s out of the oven, bubbling and golden, I know it’s going to be a hit every time.